Cinobufagin

Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans. It has similar effects to digitalis and is used in traditional Chinese medicine. Cinobufagin has been shown to have clinical applications in cancer treatment as well as immunomodulatory and analgesic properties. Cinobufagin induces apoptosis of osteosarcoma cells through inactivation of Notch signaling. Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway.

Product Specifications

CAS Number

470-37-1

Product Name Alternative

Cinobufagin | Cinobufagine | Cino-bufagin

Purity

>98% (HPLC)

Solubility

DMSO : ≥ 43 mg/mL; 97.17 mM

Smiles

CC (=O) O[C@@H]1[C@@H] ([C@]2 (CC[C@H]3[C@H] ([C@]42[C@@H]1O4) CC[C@H]1[C@@]3 (CC[C@@H] (C1) O) C) C) c1coc (=O) cc1

Molecular Formula

C26H34O6

Molecular Weight

442.55

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

(1R,2R,2aR,3aS,3bS,5aR,7S,9aS,9bR,11aS) -7-hydroxy-9a,11a-dimethyl-1- (2-oxo-2H-pyran-4-yl) hexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-2-yl acetate