SB366791
SB-366791is a potent and selective TRPV1 antagonist. SB-366791 inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. SB-366791 decreased capsaicin-induced Ca2+ influx in cultured trigeminal ganglion cells in a concentration-dependent manner (0.5-10 microM) with an IC50 of 651.9 nM. SB366791 is a more selective and in vivo also a more potent TRPV1 receptor antagonist than capsazepine in the rat therefore, it may promote the assessment of the therapeutic utility of TRPV1 channel blockers.
Product Specifications
CAS Number
472981-92-3
Product Name Alternative
SB-366791 | SB 366791 | SB366791
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 39 mg/mL 135.54 mM; H2O : < 0.1 mg/mL
Smiles
COC1=CC=CC (=C1) NC (=O) /C=C/C2=CC=C (C=C2) Cl
Molecular Formula
C16H14ClNO2
Molecular Weight
287.74
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (4-chlorophenyl) -N- (3-methoxyphenyl) -2-propenamide
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