Rhynchophylline
Rhynchophylline can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in cultured neurons in vitro. Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia.
Product Specifications
CAS Number
76-66-4
Purity
>98% (HPLC)
Solubility
DMSO : 33.33 mg/mL 86.69 mM; H2O : < 0.1 mg/mL
Smiles
CCC1CN2CCC3 (C2CC1C (=COC) C (=O) OC) C4=CC=CC=C4NC3=O
Molecular Formula
C22H28N2O4
Molecular Weight
384.47
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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