Rosmanol
Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and anxiolysis. Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Rosmanol has anti-inflammatory activity, it potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways.
Product Specifications
CAS Number
80225-53-2
Product Name Alternative
Rosmanol
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (288.67 mM)
Smiles
CC (C) c1cc2[C@H] (O) [C@H]3OC (=O) [C@@]4 (CCCC (C) (C) [C@H]34) c2c (O) c1O
Molecular Formula
C20H26O5
Molecular Weight
346.42
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(4bR,8aS,9S,10S) -3,4,10-trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b- (epoxymethano) phenanthren-12-one
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