BTB-1
BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A, which was identified by Catarinella et al. during a highthroughput screen against Kif18A ’s MT-stimulated ATPase activity, with an IC50 of 1.7 –1.9 M . It is selective within the kinesin subgroup of Kif4, Eg5, MKLP-1, MKLP-2, MPP1, CENP-E and MCAK, and during in vitro motility assays Kif18A ’s MT gliding ability was blocked by the addition of BTB-1 in a reversible manner. BTB-1 was found to be ATP competitive and MT uncompetitive, only inhibiting the ATPase activity of the MT-bound motor protein. BTB-1 could serve as a valuable tool in disentangling the nature of Kif18A ’s double functionality within mitosis and assessing for potential therapeutic utilities.
Product Specifications
CAS Number
86030-08-2
Product Name Alternative
BTB1 | BTB 1 | BTB-1
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL; 335.90 mM
Smiles
O=S (=O) (c1ccc (Cl) cc1[N+] (=O) [O-]) c1ccccc1
Molecular Formula
C12H8ClNO4S
Molecular Weight
297.71
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-chloro-2-nitro-1- (phenylsulfonyl) benzene
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