RAGE 229
RAGE 229 is an orally active ctRAGE-DIAPH1 inhibitor. RAGE 229 can inhibit the intracellular RAGE signaling by inhibiting the interaction between the cytoplasmic tail of RAGE (ctRAGE) and Diaphanous-1 (DIAPH1) [1].
Product Specifications
CAS Number
2143072-85-7
UNSPSC
12352005
Target
Transmembrane Glycoprotein
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/rage-229.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
CC(NC1=CC=C(C2=NC3=CC(C#N)=CC=C3C(CN4CCOCC4)=C2)C=C1)=O
Molecular Formula
C23H22N4O2
Molecular Weight
386.45
References & Citations
[1]Michaele B Manigrasso, et al. Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice. Sci Transl Med. 2021 Nov 24;13 (621) :eabf7084.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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