Lodoxamide
Lodoxamide is a potent agonist of GPR35 with an EC50 value of 1.61 nM in a β-arrestin-2 interaction assay using CHO-K1 cells expressing the human receptor. It inhibits histamine release induced by compound 48/80 (Item No. 22173), anti-IgE, or A23187 (Item No. 11016) in isolated rat peritoneal mast cells (IC50s = 0.1-50 μM) and inhibits A23187-induced calcium influx in mast cells. It reduces antigen-induced histamine release from rat conjunctival tissue by 46% in vitro when used at a concentration of 10 μg/ml. Lodoxamine (0.1 and 10%, w/v) reduces the immediate hypersensitivity response in rat conjunctiva in vivo in a dose-dependent manner and reduces mast cell degranulation in a topical ovalbumin challenge. Formulations containing lodoxamide have been used in the treatment of vernal conjunctivitis and keratitis.
Product Specifications
CAS Number
53882-12-5
Product Name Alternative
Lodoxamide | Lodoxamidum | Lodoxamida
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 30 mg/mL; 96.27 mM
Smiles
OC (=O) C (=O) Nc1cc (cc (NC (=O) C (O) =O) c1Cl) C#N
Molecular Formula
C11H6ClN3O6
Molecular Weight
311.63
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,2'- ((2-chloro-5-cyano-1,3-phenylene) bis (azanediyl) ) bis (2-oxoacetic acid)
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