Pentagastrin
Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test. Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system. (In Vitro) :Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) increases intracellular Ca2+ in a dose-dependent manner with a maximal increase of 2.77-fold.Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) bounds dose dependently to GH3 cells. (In Vivo) :Pentagastrin (ICI-50123) (80 μg/kg/h; i.v.; male Sprague-Dawley rats) protects rat gastric mucosa from acidified aspirin injury.
Product Specifications
CAS Number
5534-95-2
Product Name Alternative
Pentagastrin | NCGC00183362-01 | Pentagastrinum | Peptavlon
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 34 mg/mL; 44.28 mM
Smiles
CSCC[C@H] (NC (=O) [C@H] (Cc1c[nH]c2ccccc12) NC (=O) CCNC (=O) OC (C) (C) C) C (=O) N[C@@H] (CC (O) =O) C (=O) N[C@@H] (Cc1ccccc1) C (N) =O
Molecular Formula
C37H49N7O9S
Molecular Weight
767.89
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
ZNF506, NT (ZNF506, Zinc finger protein 506) (Biotin)
ZNF506, NT (ZNF506, Zinc finger protein 506) (Biotin)