Mouse Monoclonal [clone BED5] (IgG1) to Human TRF1 / TERF1
Product Specifications
Gene Name
[TRF1]
NCBI Gene ID
7013
Reactivity
Human
Storage Conditions
Short term 4 °C, long term aliquot and store at -20 °C, avoid freeze thaw cycles.
Specificity
Recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60kD protein. Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage. Reported to work in Western blotting applications.
Other Gene Names
[TERF1; TERF1; TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS; PIN2; TRBF1; TRF; TRF1]
Short Name
[TRF1 / TERF1]
Other Product Names
[telomeric repeat-binding factor 1 isoform 1; Telomeric repeat-binding factor 1; telomeric repeat-binding factor 1; NIMA-interacting protein 2; telomeric protein Pin2/TRF1; TTAGGG repeat-binding factor 1; telomeric repeat binding factor (NIMA-interacting) 1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1]
NCBI GI Number
189409142
NCBI Accession Number
NP_059523.2
NCBI GB Accession Number
NM_017489.2
Uniprot Accession Number
P54274
Available Sizes
Curated Selection
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