TAS120
TAS-120 is a novel potent and highly selective FGFR inhibitor used for antitumor treatment. (In Vitro) :Futibatinib (TAS-120) covalently binds to a highly conserved P-loop cysteine residue in the ATP pocket of FGFR. (In Vivo) :Futibatinib (TAS-120) (3, 30, 100 mg/kg/day, p.o.) exerts an anti-tumor effect in mice. Futibatinib (TAS-120) shows anti-tumor effect by administering at moderate intervals, such as intermittent administration of every other day dosing and 2 times/week, and reducing the sustained elevation and weight suppression blood phosphorus level, and take a antitumor effective as daily administration.
Product Specifications
CAS Number
1448169-71-8
Product Name Alternative
Futibatinib | FGFR-IN-1
Purity
>98% (HPLC)
Solubility
DMSO:≥ 29 mg/mL (69.30 mM)
Smiles
COc1cc (OC) cc (c1) C#Cc1nn ([C@H]2CCN (C2) C (=O) C=C) c2ncnc (N) c12
Molecular Formula
C22H22N6O3
Molecular Weight
418.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-[ (3S) -3-[4-amino-3-[2- (35-dimethoxyphenyl) ethynyl]-1H-pyrazolo[34-d]pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-one
Available Sizes
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