Selegiline hydrochloride

Selegiline hydrochloride is a selective reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM) . Monoamine oxidase (MAO) inhibitors have utility in ameliorating a variety of neurological conditions including depression. (In Vitro) :Selegiline (1 nM-1 μM) hydrochloride inhibits recombinant human MAO-B in a concentration-dependent manner.Selegiline (10 mM) hydrochloride increases the efflux of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) from the rat hypothalamus in vitro. Selegiline hydrochloride inhibits the efflux of dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) in a dose-dependent manner. (In Vivo) :Selegiline (1 mg/kg; i.p. daily for 24 days) hydrochloride reduces Cocaine self-administration of mice and does not affect Cocaine-caused body weight loss. Selegiline hydrochloride reduces 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in frontal cortex.