BIIL-260 (hydrochloride)

BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B (4) receptor LTB4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB4 receptor on isolated human neutrophil cell membranes with Ki values of 1.7 nM[1].

Product Specifications

CAS Number

[192581-24-1]

Product Name Alternative

Xanthothricin; Toxoflavine; PKF-118-310

UNSPSC

12352005

Target

Leukotriene Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/biil-260-hydrochloride.html

Purity

99.90

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

N=C(C1=CC=C(OCC2=CC=CC(COC3=CC=C(C(C)(C4=CC=C(O)C=C4)C)C=C3)=C2)C=C1)N.[H]Cl

Molecular Formula

C30H31ClN2O3

Molecular Weight

503.03

References & Citations

[1]Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B (4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297 (1) :458-66.