L189
L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ) . L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. L189 will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents.
Product Specifications
CAS Number
64232-83-3
Product Name Alternative
L189 | L 189 | L-189
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 33 mg/mL; 33.99 mM
Smiles
Nc1[nH]c (=S) [nH]c (=O) c1\N=C\c1ccccc1
Molecular Formula
C11H10N4OS
Molecular Weight
246.29
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -6-amino-5- (benzylideneamino) -2-thioxo-2,3-dihydropyrimidin-4 (1H) -one
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