ICRT 14
ICRT14 is a potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling in a reporter assay in vitro (IC50 = 40.3 nM) . It inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) in quantitative reporter assays of β-catenin/Tcf4 binding (Ki = 53.51 μM) .
Product Specifications
CAS Number
677331-12-3
Product Name Alternative
ICRT14 | iCRT-14 | iCRT 14 | Wnt inhibitor
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 29 mg/mL; 77.24 mM
Smiles
O=C4S\C (=C/c2cc (C) n (c1cccnc1) c2C) C (=O) N4c3ccccc3
Molecular Formula
C21H17N3O2S
Molecular Weight
375.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-[[2,5-dimethyl-1- (3-pyridinyl) -1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione
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