T863
T-863 (DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. IC50 value: Target: DGAT1 T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.
Product Specifications
CAS Number
701232-20-4
Product Name Alternative
T863, T 863, T-863
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 50 mg/mL; 126.75 mM
Smiles
O=C (O) C[C@@H]1CC[C@H] (CC1) c2ccc (cc2) C4=Nc3c (ncnc3N) OC4 (C) C
Molecular Formula
C22H26N4O3
Molecular Weight
394.47
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Trans-4-[4- (4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl) phenyl]cyclohexaneacetic acid
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