VER-49009
VER-49009 is a potent HSP90 inhibitor. VER-49009 inhibits Hsp90 with an IC50 value of 47 nM. VER-49009 produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis.
Product Specifications
CAS Number
558640-51-0
Product Name Alternative
VER49009 | VER 49009 | VER-49009
Purity
>98% (HPLC)
Solubility
DMSO : 100 mg/mL 257.85 mM; H2O : < 0.1 mg/mL
Smiles
C1 (c (cc (c (c1) c1c (c ([nH]n1) C (=O) NCC) c1ccc (cc1) OC) O) O) Cl
Molecular Formula
C19H18ClN3O4
Molecular Weight
387.82
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (5-chloro-2,4-dihydroxyphenyl) -N-ethyl-4- (4-methoxyphenyl) -1H-pyrazole-5-carboxamide
Available Sizes
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