Monastrol
Monastrol is a kinesin Eg5 inhibitor. Induction of apoptosis by monastrol is independent of the spindle checkpoint. Monastrol binds to the KSP-ADP complex, forming a KSP-ADP- monastrol ternary complex, which cannot bind to microtubules productively and cannot undergo further ATP-driven conformational changes.
Product Specifications
CAS Number
254753-54-3
Product Name Alternative
Monastrol
Purity
>98% (HPLC)
Smiles
CCOC (=O) C1=C (NC (=S) NC1C2=CC (=CC=C2) O) C
Molecular Formula
C14H16N2O3S
Molecular Weight
292.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Ethyl 4- (3-hydroxyphenyl) -6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
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