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Hexamethylene amiloride

HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 μM) . It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 μM for various NHE isoforms. HMA also blocks ASIC3 channels by 51% at 20 μM.

Product Specifications

CAS Number

1428-95-1

Product Name Alternative

Hexamethylene amiloride | HMA

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : 100 mg/mL (320.75 mM)

Smiles

NC (=N) NC (=O) C1=C (N) N=C (N2CCCCCC2) C (Cl) =N1

Molecular Formula

C12H18ClN7O

Molecular Weight

311.77

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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