25-Hydroxycholesterol
25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs) . It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis after an acute dietary cholesterol challenge. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.
Product Specifications
CAS Number
2140-46-7
Purity
>98% (HPLC)
Solubility
Ethanol: 20 mg/mL; Chloroform: 50 mg/mL
Smiles
C[C@H] (CCCC (C) (C) O) [C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H] (O) CC[C@]4 (C) [C@H]3CC[C@]12C
Molecular Formula
C27H46O2
Molecular Weight
402.65
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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