Aminoadipic acid

Aminoadipic acid (2-aminoadipate) is a metabolite in the principal biochemical pathway of lysine. It is an intermediate in the metabolism (i.e. breakdown or degradation) of lysine and saccharopine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor N-methyl-D-aspartate (NMDA) . Aminoadipic acid has also been shown to inhibit the production of kynurenic acid a broad spectrum excitatory amino acid receptor antagonist in brain tissue slices.