3-Hydroxyanthranilic acid

3-Hydroxyanthranilic acid also known as 2-amino-3-hydroxy-benzoate or 3-ohaa belongs to the class of organic compounds known as hydroxybenzoic acid derivatives. 3-Hydroxyanthranilic acid has been found in human epidermis and bladder tissues and has also been detected in multiple biofluids such as urine and blood. Within the cell 3-hydroxyanthranilic acid is primarily located in the cytoplasm. 3-Hydroxyanthranilic acid exists in all eukaryotes ranging from yeast to humans. 3-Hydroxyanthranilic acid participates in a number of enzymatic reactions. In particular 3-Hydroxyanthranilic acid and L-alanine can be biosynthesized from L-3-hydroxykynurenine; which is catalyzed by the enzyme kynureninase. Furthermore 3-Hydroxyanthranilic acid can be converted into cinnavalininate through its interaction with the enzyme catalase. Furthermore L-Alanine and 3-hydroxyanthranilic acid can be biosynthesized from 3-hydroxy-L-kynurenine through its interaction with the enzyme kynureninase. Furthermore 3-Hydroxyanthranilic acid can be converted into 2-amino-3-carboxymuconic acid semialdehyde; which is catalyzed by the enzyme 3-hydroxyanthranilate 34-dioxygenase. Furthermore 3-Hydroxyanthranilic acid can be converted into 2-amino-3-carboxymuconic acid semialdehyde through the action of the enzyme 3-hydroxyanthranilate 34-dioxygenase. Finally L-Alanine and 3-hydroxyanthranilic acid can be biosynthesized from 3-hydroxy-L-kynurenine; which is mediated by the enzyme kynureninase. In humans 3-hydroxyanthranilic acid is involved in the tryptophan metabolism pathway.