Juglone
Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM) . Juglone also blocks transcription by RNA polymerases I II and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction both through Pin1-independent mechanisms.
Product Specifications
CAS Number
481-39-0
Product Name Alternative
Regianin | 5-Hydroxy-14-naphthoquinone
Purity
>98% (HPLC)
Solubility
DMSO: 15 mg/mL; Ethanol: 15 mg/mL
Smiles
Oc1cccc2C (=O) C=CC (=O) c12
Molecular Formula
C10H6O3
Molecular Weight
174.15
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-hydroxynaphthalene-14-dione
Available Sizes
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