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EGFR-TK-IN-4

EGFR-TK-IN-4 (compound 10k) is a potent and selective EGFR-TK inhibitor. EGFR-TK-IN-4 can induce apoptosis . EGFR-TK-IN-4 has antitumor activity[1].

Product Specifications

CAS Number

3053485-72-3

UNSPSC

12352005

Target

Apoptosis; EGFR

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-tk-in-4.html

Concentration

10mM

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=NC=C(C2=CN=C(SC(C3=CC=CC(NS(C4=CC(F)=CC=C4F)(=O)=O)=C3C)=N5)C5=C2)C=N1

Molecular Formula

C23H16F2N6O2S2

Molecular Weight

510.54

References & Citations

[1]T Borude AS, et al. Design and synthesis of novel Thiazolo[5,4-b]pyridine derivatives as potent and selective EGFR-TK inhibitors targeting resistance Mutations in non-small cell lung cancer. Eur J Med Chem. 2024 Oct 5;276:116727.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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