5-Nitroindole
5-Nitroindole is a mutagenic nitroarene and universal base analog. 5-Nitroindole significantly reduces the cellular adenylate energy charge by decreasing ATP levels and increasing AMP levels. 5-Nitroindole inhibits lipid peroxidation[1][2].
Product Specifications
CAS Number
6146-52-7
UNSPSC
12352200
Hazard Statement
H302, H318
Target
ATP Synthase; Biochemical Assay Reagents
Type
Biochemical Assay Reagents
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/5-nitroindole.html
Purity
99.30
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=[N+]([O-])C1=CC2=C(NC=C2)C=C1
Molecular Formula
C8H6N2O2
Molecular Weight
162.15
Precautions
H302, H318
References & Citations
[1]Dubin M, et al. Effect of 5-nitroindole on adenylate energy charge, oxidative phosphorylation, and lipid peroxidation in rat hepatocytes. Biochem Pharmacol. 1994 Oct 7;48 (7) :1483-92. |[2]Loakes D, et al. 5-Nitroindole as an universal base analogue. Nucleic Acids Res. 1994 Oct 11;22 (20) :4039-43.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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