T-26c
T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor (IC50: 6.75 pM) . (In Vitro) :T-26c significantly inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1β and oncostatin M stimulated cartilage. (In Vivo) :T-26c is well absorbed in all species at the oral dose of 10–20 mg/kg. Oral administration of the disodium salt formulations of T-26c to guinea pigs results in significant increases in AUC (8357 ng h/mL) and Cmax (1445 ng/ mL) compared with those of the free acid T-26c (AUC = 6478 ng h/ mL and Cmax= 911 ng/mL) .
Product Specifications
CAS Number
869296-13-9
Purity
>98% (HPLC)
Solubility
DMSO: 12 mg/mL (25.03 mM) ; Water: Insoluble
Smiles
COc1cccc (CNC (=O) c2nc3scc (COCc4ccc (cc4) C (O) =O) c3c (=O) [nH]2) c1
Molecular Formula
C24H21N3O6S
Molecular Weight
479.51
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- (((2- ((3-methoxybenzyl) carbamoyl) -4-oxo-34-dihydrothieno[23-d]pyrimidin-5-yl) methoxy) methyl) benzoic acid
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
EIF2C1, NT (Protein Argonaute-1, Argonaute1, hAgo1, Eukaryotic Translation Initiation Factor 2C 1, eIF-2C 1, eIF2C 1, Putative RNA-binding Protein Q99, AGO1) (HRP)
EIF2C1, NT (Protein Argonaute-1, Argonaute1, hAgo1, Eukaryotic Translation Initiation Factor 2C 1, eIF-2C 1, eIF2C 1, Putative RNA-binding Protein Q99, AGO1) (HRP)
