Bakuchiol
Bakuchiol is a phytoestrogen isolated from the seeds of Psoralea corylifolia L; has anti-tumor effects. IC50 value: Target: in vitro: Bakuchiol reduced mitochondrial membrane potential (Psim) of cells in a concentration- and time-dependent manner, showing a more potent effect than that of resveratrol. S phase arrest, caspase 9/3 activaton, p53 and Bax up-regulation, as well as Bcl-2 down-regulation were observed in bakuchiol-treated A549 cells. UGT2B7 was inhibited by the strongest intensity. The noncompetitive inhibition was demonstrated by the results obtained from Dixon plot and Lineweaver-Burk plot. The Ki value was calculated to be 10.7 μM. Bakuchiol was found to be naturally occurring potent inhibitors of hCE2, with low Ki values ranging from 0.62μM to 3.89μM.
Product Specifications
CAS Number
10309-37-2
Product Name Alternative
(S) - (+) -Bakuchiol
Purity
>98% (HPLC)
Solubility
DMSO : 62.5 mg/mL (243.78 mM; Need ultrasonic) ; H2O : < 0.1 mg/mL (insoluble)
Smiles
OC1=CC=C (/C=C/[C@] (C) (C=C) CC/C=C (C) \C) C=C1
Molecular Formula
C??H??O
Molecular Weight
256.38
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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