Tubastatin A TFA
Potent, selective HDAC6 inhibitor (IC50 values are 4 and 900 nM for HDAC6 and HDAC8 respectively) . Inhibits LPS-induced cytokine production in macrophages (IC50 values are 272 and 712 nM for TNF-α and IL-6 respectively) . Induces α-tubulin hyperacetylation. Shows anti-inflammatory and peripheral neuroprotective effects in vivo.
Product Specifications
CAS Number
1239262-52-2
Field of Research
Immunology & Inflammation
Purity
>98% (HPLC)
Solubility
Soluble in 1:10 DMSO:PBS (pH7.2) (~0.1 mg/mL), ethanol (~0.2 mg/mL), DMF (~5 mg/mL), and DMSO (~5 mg/mL) .
Smiles
CN1CCC2=C (C1) C3=CC=CC=C3N2CC4=CC=C (C=C4) C (=O) NO.C (=O) (C (F) (F) F) O
Molecular Formula
C22H22F3N3O4
Molecular Weight
449.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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