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Tubastatin A TFA

Potent, selective HDAC6 inhibitor (IC50 values are 4 and 900 nM for HDAC6 and HDAC8 respectively) . Inhibits LPS-induced cytokine production in macrophages (IC50 values are 272 and 712 nM for TNF-α and IL-6 respectively) . Induces α-tubulin hyperacetylation. Shows anti-inflammatory and peripheral neuroprotective effects in vivo.

Product Specifications

CAS Number

1239262-52-2

Field of Research

Immunology & Inflammation

Purity

>98% (HPLC)

Solubility

Soluble in 1:10 DMSO:PBS (pH7.2) (~0.1 mg/mL), ethanol (~0.2 mg/mL), DMF (~5 mg/mL), and DMSO (~5 mg/mL) .

Smiles

CN1CCC2=C (C1) C3=CC=CC=C3N2CC4=CC=C (C=C4) C (=O) NO.C (=O) (C (F) (F) F) O

Molecular Formula

C22H22F3N3O4

Molecular Weight

449.4

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Available Sizes

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