What is the catalog number for APG-1387?

The catalog number for APG-1387 is orb1220178.

What sizes are available for APG-1387?

APG-1387 is available in the following size(s): 100 mg, 200 mg, 500 mg, 1 g, 5 mg, 10 mg.

How many pack sizes does APG-1387 come in?

APG-1387 is available in 6 different pack sizes.

Is APG-1387 in stock?

APG-1387 is currently made to order / not held in immediate stock. Contact us for lead time.

APG-1387

APG-1387, a bivalent SMAC mimetic and an IAP antagonist, blocks the activity of IAPs family proteins (XIAP, cIAP-1, cIAP-2, and ML-IAP) . APG-1387 induces degradation of cIAP-1 and XIAP proteins, as well as caspase-3 activation and PARP cleavage, which leads to apoptosis. APG-1387 can be used for the research of hepatocellular carcinoma, ovarian cancer, and nasopharyngeal carcinoma.

Product Specifications

CAS Number

1570231-89-8

Purity

>98% (HPLC)

Solubility

DMSO : 50 mg/mL (43.20 mM; Need ultrasonic)

Smiles

O=S (C1=CC=CC (S (=O) (N (C[C@@H]2NC ([C@@H] (NC) C) =O) CC[C@] (CC[C@H]3C (NC (C4=CC=CC=C4) C5=CC=CC=C5) =O) ([H]) N3C2=O) =O) =C1) (N (C[C@@H]6NC ([C@@H] (NC) C) =O) CC[C@] (CC[C@H]7C (NC (C8=CC=CC=C8) C9=CC=CC=C9) =O) ([H]) N7C6=O) =O