Pyridostatin (RR82)
Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest.Pyridostatin hydrochloride is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin hydrochloride causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin hydrochloride induces the formation of DNA DSBs. Remarkably, Pyridostatin hydrochloride (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level.
Product Specifications
CAS Number
1781882-65-2
Product Name Alternative
RR82 hydrochloride
Purity
>98% (HPLC)
Solubility
H2O : 50 mg/mL (64.19 mM; Need ultrasonic)
Smiles
O=C (C1=CC (OCCN) =CC (C (NC2=NC3=C (C (OCCN) =C2) C=CC=C3) =O) =N1) NC4=CC (OCCN) =C5C=CC=CC5=N4.Cl.Cl.Cl.Cl.Cl
Molecular Formula
C??H??Cl?N?O?
Molecular Weight
778.94
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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