JBJ-04-125-02
JBJ-04-125-02 (0-1000 nM; 72 hours; H1975 cells) treatment could inhibit cell proliferation of H1975 cells at low nanomolar concentrations.JBJ-04-125-02 treatment also inhibits cell proliferation in Ba/F3 cells stably transfected with EGFRL858R, EGFRL858R/T790M, or EGFRL858R/T790M/C797S mutations.The ability of JBJ-04-125-02 (0.01-10 μM) to inhibit EGFR phosphorylation using Ba/F3, H1975 and NIH-3T3 cells is examined. JBJ-04-125-02 demonstrates mutant selectivity by inhibiting mutant EGFR and downstream AKT and ERK1/2 phosphorylation.
Product Specifications
CAS Number
2060610-53-7
Purity
>98% (HPLC)
Smiles
O=C (NC1=NC=CS1) [C@@H] (C2=CC (F) =CC=C2O) N (CC3=C4C=C (C5=CC=C (N6CCNCC6) C=C5) C=C3) C4=O
Molecular Formula
C??H??FN?O?S
Molecular Weight
543.61
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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