MOUSE ANTI HUMAN SIGLEC-10:RPE

Prior to reconstitution store at 4 °C. After reconstitution store at 4 °C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.<br>Shelf Life: 12 months from date of reconstitution.

Clone 5G6 specifically recognises human Siglec-10 (Sialic acid-binding Ig-like lectin 10), a putative adhesion molecule, and member of the Ig superfamily, expressed by monocytes, B cells, eosinophils, and at a higher level by a subpopulation of CD16+CD56- natural killer (NK) cells. <br> <br>Structurally, Siglec-10 is most similar to the CD33-related group of Siglecs, and preferentially binds to glycoconjugates containing alpha-2,3- or alpha-2,6-linked sialic acid. Studies have shown that Siglec-10 acts as a substrate for VAP-1 (Vascular adhesion protein-1), a glycoprotein expressed on endothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking, see Kive, E. et al. for details. This interaction between Siglec-10 and VAP-1, implicates Siglec-10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment. <br> <br>Studies have shown that clone 5G6 does not cross-react with Siglecs 3, 5, 7, 8 and 9.

[sialic acid-binding Ig-like lectin 10 isoform 2; Sialic acid-binding Ig-like lectin 10; sialic acid-binding Ig-like lectin 10; sialic acid binding Ig-like lectin 10 Ig-like lectin 7; siglec-like gene 2; siglec-like protein 2; sialic acid binding Ig-like lectin 10; Siglec-like protein 2]