YM90K hydrochloride
YM90K hydrochloride is an antagonist of AMPA receptor.In a global ischemia model, YM90K (15 mg/kg i.p. x 3), NBQX (30 mg/kg i.p. x 3) and CNQX (60 mg/kg i.p. x 3) significantly prevented the delayed neuronal death in the hippocampal CA1 region in Mongolian gerbils when administered 1 h after 5-min ischemia. In addition, the therapeutic time window for the neuroprotective effect of YM90K (30 mg/kg i.p. x 3) was 6 h. In a focal ischemia model, YM90K (30 mg/kg i.v. bolus+10 mg/kg/h for 4 h) reduced the volume of ischemic damage in the cerebral cortex in F344 rats.
Product Specifications
CAS Number
154164-30-4
Product Name Alternative
6- (1H-imidazol-1-yl) -7-nitro-2,3 (1H,4H) -
Purity
>98% (HPLC)
Smiles
Cl.[O-][N+] (=O) c1cc2[nH]c (=O) c (=O) [nH]c2cc1-n1ccnc1
Molecular Formula
C11H8ClN5O4
Molecular Weight
309.66
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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