ECF506
ECF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM) eCF506, the first small molecule with subnanomolar IC50 for SRC that requires 3 orders of magnitude greater concentration to inhibit ABL. eCF506 exhibits excellent water solubility, an optimal DMPK profile and oral bioavailability, halts SRC-associated neuromast migration in zebrafish embryos without inducing life-threatening heart defects, and inhibits SRC phosphorylation in tumor xenografts in mice.
Product Specifications
CAS Number
1914078-41-3
Purity
>98% (HPLC)
Solubility
DMSO:62.5 mg/mL (122.40 mM; Need ultrasonic)
Smiles
COc1cc (ccc1NC (=O) OC (C) (C) C) -c1nn (CCN2CCC (CC2) N (C) C) c2ncnc (N) c12
Molecular Formula
C26H38N8O3
Molecular Weight
510.63
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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