11-Keto-beta-boswellic acid
11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenaseA total of ten transformed compounds were isolated and purified, and their chemical structures were characterized as 7β-hydroxy-11-keto-β-boswellic acid; 7β, 15α±-dihydroxy-11-keto-β-boswellic acid ; 7β, 16β-dihydroxy-11-keto-β-boswellic acid; 7β, 16α±-dihydroxy-11-keto-β-boswellic acid; 7β, 22β-dihydroxy-11-keto-β-boswellic acid; 7β, 21β-dihydroxy-11-keto-β-boswellic acid; 7β, 20β-dihydroxy-11-keto-β-boswellic acid; 7β, 30-dihydroxy-11-keto-β-boswellic acid; 3α±, 7β-dihydroxy-11-oxours-12-ene-24, 30-dioic acid and 3α±, 7β-dihydroxy-30- (2-hydroxypropanoyloxy) -11-oxours-12-en-24-oic acid by various spectroscopic methods. The biotransformation processes include hydroxylation, oxidation and esterification. Primary structure-activity relationships (SAR) of inhibitory effects on NO production in RAW 264.7 macrophage cells are discussed.
Product Specifications
CAS Number
17019-92-0
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (106.23 mM)
Smiles
[H][C@@]12[C@@H] (C) [C@H] (C) CC[C@]1 (C) CC[C@]1 (C) C2=CC (=O) [C@]2 ([H]) [C@@]3 (C) CC[C@@H] (O) [C@] (C) (C (O) =O) [C@]3 ([H]) CC[C@@]12C
Molecular Formula
C30H46O4
Molecular Weight
470.68
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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