P-MPPI hydrochloride
P-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects. pre-treatment with p-MPPI (5 mg/kg intraperitoneal (i.p.) ) 30 min before 8-OH-DPAT (0.375 mg/kg subcutaneously (s.c.) ) reduced the effect of 8-OH-DPAT on waking and REM sleep. Also, p-MPPI (5 and 10 mg/kg i.p.) reduced the effect of 8-OH-DPAT on locomotion and partially or completely antagonized hindlimb abduction and flat body posture. No overt behavioural change was produced by p-MPPI alone. Thus, p-MPPI behaved as a true 5-HT (1A) antagonist.
Product Specifications
CAS Number
220643-77-6
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 17.86 mg/mL (30.85 mM)
Smiles
Cl.COC1=CC=CC=C1N1CCN (CCN (C (=O) C2=CC=C (I) C=C2) C2=CC=CC=N2) CC1
Molecular Formula
C25H28ClIN4O2
Molecular Weight
578.87
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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