GOAT ANTI MOUSE CD184 (N-TERMINAL)

Store at -20 °C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.<br>Shelf Life: 18 months from date of despatch.

This item recognises an epitope within the N-terminal (NT) region of mouse CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1). <br> <br>Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B-lymphopoiesis and myelopoiesis. CD184 <br>is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates. <br> <br>This item is reported as suitable for use in immunocytochemistry on mouse spleen leucocytes.

[C-X-C chemokine receptor type 4; C-X-C chemokine receptor type 4; C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; SDF-1 receptor; chemokine (C-X-C) receptor 4; chemokine receptor 4; fusin; leukocyte-derived seven transmembrane domain receptor; leukocyte-expressed seven-transmembrane-domain; pre-B-cell-derived chemokine receptor; stromal cell-derived factor 1 receptor; chemokine (C-X-C motif) receptor 4; Fusin; Leukocyte-derived seven transmembrane domain receptor; LESTR; Pre-B-cell-derived chemokine receptor; PB-CKR; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD_antigen: CD184]