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Dabrafenib Mesylate

Dabrafenib Mesylate is a B-Raf inhibitor (IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively) .In human endothelial cells, Dabrafenib inhibits the release of HMGB1 and down-regulates the HMGB1-dependent inflammatory response by enhancing the expression of cell adhesion molecules (CAM) .

Product Specifications

CAS Number

1195768-06-9

Product Name Alternative

GSK2118436 Mesylate, GSK 2118436B

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

DMSO:34 mg/mL (55.22 mM)

Smiles

CS (O) (=O) =O.CC (C) (C) C1=NC (=C (S1) C1=NC (N) =NC=C1) C1=C (F) C (NS (=O) (=O) C2=C (F) C=CC=C2F) =CC=C1

Molecular Formula

C24H24F3N5O5S3

Molecular Weight

615.67

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Available Sizes

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