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UNC 0646

UNC 0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP) . UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells) ; exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells) .

Product Specifications

CAS Number

1320288-17-2

Purity

>98% (HPLC)

Solubility

DMSO:30 mg/mL (48.24 mM; Need ultrasonic)

Smiles

COC1=C (OCCCN2CCCCC2) C=C2N=C (N=C (NC3CCN (CC3) C3CCCCC3) C2=C1) N1CCCN (CC1) C (C) C

Molecular Formula

C36H59N7O2

Molecular Weight

621.9

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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