RABBIT ANTI HRK

Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.<br>Shelf Life: 18 months from date of despatch.

This item detects Harakiri (HRK), also known as DP5. HRK is a BH3 only protein of the Bcl-2 family, which promotes Bax dependent apoptosis. HRK regulates apoptosis through its interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL, and in conjunction to the mitochondrial pore forming protein p32. HRK is thought to have a specific role in initiating neuronal and haematopoietic cell apoptosis, in particular to growth factor deprivation. <br>Aberrant methylation of HRK is frequently detected in primary colorectal cancers. Despite its predicted molecular weight, HRK often migrates at 12-15kD.

[activator of apoptosis harakiri; Activator of apoptosis harakiri; activator of apoptosis harakiri; BCL2-interacting protein; BH3-interacting domain-containing protein 3; activator of apoptosis Hrk; death protein 5; harakiri, BCL2 interacting protein (contains only BH3 domain); neuronal death protein DP5; harakiri, BCL2 interacting protein; BH3-interacting domain-containing protein 3; Neuronal death protein DP5]