(R) -CR8
(R) -CR8 is a potent and selective CDK inhibitor.A delayed systemic post-LFP administration at 3 hours of CR8--a potent second-generation cyclin-dependent kinase (CDK) inhibitor--reduced CCA; cortical, hippocampal, and thalamic neuronal loss; and cortical microglial and astrocyte activation. Furthermore, CR8 treatment attenuated sensorimotor and cognitive deficits, alleviated depressive-like symptoms, and decreased lesion volume.
Product Specifications
CAS Number
294646-77-8
Product Name Alternative
CR8 , (R) -Isomer
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (115.87 mM)
Smiles
CC[C@H] (CO) Nc1nc (NCc2ccc (cc2) -c2ccccn2) c2ncn (C (C) C) c2n1
Molecular Formula
C24H29N7O
Molecular Weight
431.53
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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