ML382
ML382 is a potent and selective MrgX1 positive allosteric modulator (EC50 : 190 nM) .ML382 enhances the ability of BAM8-22 to inhibit high-voltage-activated Ca2+ channels and attenuate spinal nociceptive transmission, both BAM8-22 and ML382 effectively attenuated evoked, persistent, and spontaneous pain without causing obvious side effects. Notably, ML382 by itself attenuated both evoked pain hypersensitivity and spontaneous pain in MrgprX1 mice after nerve injury without acquiring coadministration of an exogenous agonist.
Product Specifications
CAS Number
1646499-97-9
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (277.45 mM)
Smiles
CCOc1ccccc1NC (=O) c1ccccc1NS (=O) (=O) C1CC1
Molecular Formula
C??H??NO?
Molecular Weight
360.42
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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