TBOPP
TBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors. TBOPP as a selective inhibitor of DOCK1. TBOPP dampened DOCK1-mediated invasion, macropinocytosis, and survival under the condition of glutamine deprivation without impairing the biological functions of the closely related DOCK2 and DOCK5 proteins.TBOPP treatment suppressed cancer metastasis and growth in vivo in mice.
Product Specifications
CAS Number
1996629-79-8
Purity
>98% (HPLC)
Solubility
DMSO:120 mg/mL (244.65 mM; Need ultrasonic)
Smiles
FC (F) (F) c1cccc (c1) -c1ccc (cc1) C (=O) Cn1cc (ccc1=O) S (=O) (=O) N1CCCC1
Molecular Formula
C24H21F3N2O4S
Molecular Weight
490.49
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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