Coenzyme A
Coenzyme A is an obligatory cofactor in all living cells synthesized from pantothenate (Vitamin B5), adenosine triphosphate (ATP), and cysteine.Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT. Many human pathologies, including cancer, diabetes, and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives.
Product Specifications
CAS Number
85-61-0
Purity
>98% (HPLC)
Solubility
In Vitro: H2O : 125 mg/mL (162.86 mM)
Smiles
CC (C) (COP (O) (=O) OP (O) (=O) OC[C@H]1O[C@H] ([C@H] (O) [C@@H]1OP (O) (O) =O) n1cnc2c (N) ncnc12) [C@@H] (O) C (=O) NCCC (=O) NCCS
Molecular Formula
C21H36N7O16P3S
Molecular Weight
767.53
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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