Ceefourin 1
Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.Ceefourin 1 and Ceefourin 2, that inhibit transport of a broad range of MRP4 substrates, yet are highly selective for MRP4 over other ABC transporters, including P-glycoprotein (P-gp), ABCG2 (Breast Cancer Resistance Protein; BCRP) and MRP1 (multidrug resistance protein 1; ABCC1) . Both compounds are more potent MRP4 inhibitors in cellular assays than the most widely used inhibitor, MK-571, requiring lower concentrations to effect a comparable level of inhibition. Furthermore, Ceefourin 1 and Ceefourin 2 have low cellular toxicity, and high microsomal and acid stability.
Product Specifications
CAS Number
315702-40-0
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 125 mg/mL (424.56 mM)
Smiles
S=C1N (C) C (CSC2=NC3=CC=CC=C3S2) =NN1
Molecular Formula
C11H10N4S3
Molecular Weight
294.42
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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