GW 6471
GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.A specific PPARα antagonist, GW6471, induced both apoptosis and cell cycle arrest at G0/G1 in VHL (+) and VHL (-) RCC cell lines (786-O and Caki-1) associated with attenuation of the cell cycle regulatory proteins c-Myc, Cyclin D1, and CDK4; this data was confirmed as specific to PPARα antagonism by siRNA methods.
Product Specifications
CAS Number
880635-03-0
Purity
>98% (HPLC)
Solubility
DMSO:120 mg/mL (193.65 mM; Need ultrasonic)
Smiles
CCC (NC[C@@H] (N/C (C) =C\C (C1=CC=C (C (F) (F) F) C=C1) =O) CC2=CC=C (OCCC3=C (C) OC (C4=CC=CC=C4) =N3) C=C2) =O
Molecular Formula
C35H36F3N3O4
Molecular Weight
619.67
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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