(S, R, S) -AHPC-PEG3-N3
(S, R, S) -AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S, R, S) -AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker.
Product Specifications
CAS Number
1797406-80-4
Product Name Alternative
VH032-PEG3-N3
Field of Research
Cell Biology
Purity
>98% (HPLC)
Solubility
DMSO:50 mg/mL (77.43 mM; Need ultrasonic)
Smiles
O=C (N[C@@H] (C (C) (C) C) C (N (C[C@H] (O) C1) [C@@H]1C (NCC2=CC=C (C (SC=N3) =C3C) C=C2) =O) =O) COCCOCCOCCN=[N+]=[N-]
Molecular Formula
C30H43N7O7S
Molecular Weight
645.77
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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