Phellodendrine (chloride)
Phellodendrine chloride is an orally active plant alkaloid. Phellodendrine chloride inhibits the proliferation of KRAS-mutated pancreatic cancer cells by suppressing macropinocytosis and glutamine metabolism, inducing ROS accumulation and mitochondrial apoptosis. Phellodendrine chloride promotes autophagy by activating the AMPK/mTOR pathway, alleviating intestinal damage in ulcerative colitis. Phellodendrine chloride can alleviate gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway. Phellodendrine chloride suppresses allergic reactions by altering the conformation of MRGPRB3/MRGPRX2 protein, thereby inhibiting the activation of PKC and subsequent downstream MAPK and NF-κB signaling. Phellodendrine chloride inhibits the AKT/NF-κB pathway and down-regulates the expression of COX-2, thereby protecting zebrafish embryos from oxidative stress. Phellodendrine chloride has an anti-major depressive disorder (MDD) effect by down-regulating CHRM1, HTR1A, and the PI3K/Akt signaling pathway[1][2][3][4][5][6].
Product Specifications
CAS Number
104112-82-5
UNSPSC
12352005
Hazard Statement
H302
Target
Akt; AMPK; Apoptosis; Autophagy; COX; Interleukin Related; MMP; mTOR; NF-κB; p38 MAPK; PI3K; PKC; Reactive Oxygen Species (ROS) ; STAT
Type
Natural Products
Related Pathways
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/phellodendrine-chloride.html
Purity
99.68
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[N@@+]12CCC3=CC(OC)=C(O)C=C3[C@]1([H])CC4=CC(O)=C(OC)C=C4C2.[Cl-]
Molecular Formula
C20H24ClNO4
Molecular Weight
377.86
Precautions
H302
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
IL-1; IL-4; IL-6; MMP-3; STAT3
Available Sizes
Frequently Asked Questions
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