Sulbutiamine
Sulbutiamine is an antioxidant that act by inhibiting oxidative stress induced retinal ganglion cell death. (In Vitro) :Sulbutiamine shows neuroprotective effects on hippocampal CA1 pyramidal neurons subjected to oxygen-glucose deprivation. Sulbutiamine enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH and GST activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF.
Product Specifications
CAS Number
3286-46-2
Product Name Alternative
Bisibuthiamine
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:75 mg/mL (106.70 mM)
Smiles
CC (C) C (=O) OCC\C (SS\C (CCOC (=O) C (C) C) =C (\C) N (Cc1cnc (C) nc1N) C=O) =C (/C) N (Cc1cnc (C) nc1N) C=O
Molecular Formula
C32H46N8O6S2
Molecular Weight
702.89
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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