Rubitecan
Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner.Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. (In Vitro) :Rubitecan (RFS 2000) inhibits U-CH1, U-CH2, and CCL4 cells with IC50s 0.32, 0.83, and 7.7 μM, respectively.
Product Specifications
CAS Number
91421-42-0
Product Name Alternative
RFS 2000 | 9-Nitrocamptothecin
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:125 mg/mL (317.78 mM)
Smiles
CC[C@@]1 (O) C (=O) OCc2c1cc1-c3nc4cccc ([N+] ([O-]) =O) c4cc3Cn1c2=O
Molecular Formula
C20H15N3O6
Molecular Weight
393.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(S) -4-ethyl-4-hydroxy-10-nitro-1H-pyrano[3'4':67]indolizino[12-b]quinoline-314 (4H12H) -dione
Available Sizes
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